OPTIC NERVE ATROPHY OPA1

Anyone else with the same condition?

Comments (5)

Teresa Moderator's picture

Reply to Robbo50 by Teresa Moderator

Hi Robbo50

I read your post and thought you may be interested to know that we have an Eye Health Information Service, who you can talk to about this condition. You can contact them either by phone on 020 7391 3299 or by email on eyehealth@rnib.org.uk to discuss things further.

They have also written this brief outline of the condition for information purposes.

Optic nerve atrophy OPA1 is also known as optic atrophy type 1 and it is hereditary, relating to mutations of the gene OPA1. The OPA1 gene provides instructions for making a protein that is found in cells throughout the body. This protein is important for the cell structures called mitochondria to work properly. Mitochondria are the energy-producing centres in the body's cells. Some of the cells in the retina are called retinal ganglion cells. These retinal ganglion cells are particularly sensitive to mutations of the OPA1 gene. This is because these ganglion cells require a lot of energy from the cell mitochondria to work effectively. When there are changes in the mitochondrial function due to OPA1 mutations, the retinal ganglion cells will stop working and die over time. The retinal ganglion cells have specialised extensions called axons that form the optic nerves, so when the retinal ganglion cells die, the optic nerves waste away, or atrophy, too. This optic atrophy leads to sight loss in both eyes which usually begins in childhood and worsens over time. Those affected experience a narrowing of their visual field leading to 'tunnel vision' and their colour vision is frequently affected. At present there is no effective treatment for this condition.

RNIB isn’t a medical organisation, we can only offer general information about eye conditions and their treatments. This information shouldn’t be used instead of advice from a medical professional that can examine your eye. RNIB isn’t able to recommend one treatment or therapy over another. We make every effort to make sure the information we provide is correct but we cannot accept any responsibility or liability.

Robbo50's picture

Reply to Teresa Moderator by Robbo50

Thanks very much for info Teresa much appreciated.

Teresa Moderator's picture

Reply to Robbo50 by Teresa Moderator

HI Robbo50,

Just thought you might try to open up discussion on one of our other boards, such as Ask the Community or Introduce Yourself - you may get more response. Hope this helps.

Robbo50's picture

Reply to Teresa Moderator by Robbo50

Good idea thank you.

LelaPatterson's picture

Reply to Robbo50 by LelaPatterson

I don’t, sorry. I have 2 different eye conditions to you. I have a condition in each eye; the first one’s called Optic Nerve Displasia and the second one is Optic Nerve Hypoplasia.